Endocrine Abstracts

Hypothalamic obesity has major impact on prognosis and quality of life (QoL) in childhood craniopharyngioma (CP). The pathogenic relevance of initial hypothalamic involvement versus treatment-related hypothalamic lesions is a matter of controversy.One hundred and twenty patients were recruited prospectively during 2001 and 2007 and evaluated after 3 years of follow-up. Body mass index (BMI) and QoL at diagnosis and 36 mo after diagnosis were analyzed bas...

Despite high survival rates (92%) in patients with childhood craniopharyngioma (CP), quality of life (QoL) is frequently impaired due to sequelae such as severe obesity resulting from hypothalamic involvement of CP. Based on the results of the multicenter prospective study KRANIOPHARYNGEOM 2000 radical surgery is no appropriate treatment strategy in patients with hypothalamic involvement. Furthermore, tumour progression/relapses are frequent early events in CP patients. The an...

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)Craniopharyngioma (CP), Rathke’s cyst (RC) and xanthogranuloma (XG) are closely related rare sellar masses, which share common embryogenic origin. Treatment strategies in children lack consensus, especially in terms of surgical and radiooncological treatment options.Objective: To study clinical manifestations and treatment-related outco-me in RC, XG, and CP patients.</...